Milan named their squad for the Europa League qualifier with Craiova tomorrow, including Hakan Calhanoglu, but not Ignazio Abate, while Andre Silva should start.
The Rossoneri won 1-0 in Romania last week thanks to a Ricardo Rodriguez free kick.
The second leg kicks off on Thursday at San Siro at 19.45 UK time (18.45 GMT).
Coach Vincenzo Montella has named his squad for the game and, like the first leg, there is no room for transfer-listed Carlos Bacca, Jose Sosa or Gabriel Paletta.
Calhanoglu gets his first call-up since arriving from Bayer Leverkusen at a cost of €22m.
However, Abate and Luca Antonelli are not fit enough to take part.
This time around, Andre Silva and Suso are expected to start in the trident attack, moving Giacomo Bonaventura to midfield with Franck Kessie.
Manuel Locatelli steps in for Riccardo Montolivo and Andrea Conti has shaken off a back problem to start at right-back.
Milan (probable): Donnarumma; Conti, Musacchio, Zapata, Rodriguez; Kessie, Locatelli, Bonaventura; Suso, Andre Silva, Niang
Milan squad for Craiova: Antonio Donnarumma, Gianluigi Donnarumma, Storari; Calabria, Conti, Gomez, Musacchio, Rodriguez, Zapata; Bonaventura, Calhanoglu, Kessie, Locatelli, Mauri, Montolivo; Borini, Cutrone, Niang, André Silva, Suso