Luciano Spalletti has some big choices to make for Inter, while Fiorentina could start Giovanni Simeone at San Siro tonight.
The big game of the weekend kicks off at 19.45 UK time (18.45 GMT), click here for a match preview.
New Nerazzurri boss Spalletti is still putting together his new-look squad and opted for a 4-2-3-1 throughout the summer friendlies.
Dalbert arrived from Nice only a week ago, but he is pushing for a spot in the starting XI instead of Yuto Nagatomo.
In midfield, Borja Valero seems to be the favourite to start against his old club, but for the remaining two places it’s a fight between Matias Vecino, Roberto Gagliardini and Joao Mario.
Mauro Icardi is not 100 per cent fit, but should still lead the attack with support from Antonio Candreva and Ivan Perisic.
Davide Santon is injured and Geoffrey Kondogbia has already been released to undergo his Valencia medical.
Fiorentina Coach Stefano Pioli had a short-lived experience at Inter last season and makes his Fiorentina debut back at the scene of the crime.
The Viola have completely revamped their squad this summer and the new arrivals only really started flooding in over the last week.
Bruno Gaspar and Vitor Hugo should start, having been in Florence for a while now, but the real surprise could be in attack.
Simeone only completed his transfer from Genoa on Wednesday evening, yet he may well be preferred to Khouma Babacar, whose performances in pre-season were not impressive.
Nikola Kalinic is naturally unavailable, as he prepares to have his Milan medical tomorrow.
Gil Dias and Valentin Eysseric could also be launched straight into the initial line-up with Marco Benassi.
Federico Chiesa is suspended and Riccardo Saponara carrying an injury, so Jordan Veretout and Carlos Sanchez are more potential new faces.
Inter: Handanovic; D'Ambrosio, Skriniar, Miranda, Dalbert; Gagliardini, Borja Valero; Candreva, Joao Mario, Perisic; Icardi
Inter bench: Padelli, Berni, Ranocchia, Vanheusden, Nagatomo, Ansaldi, Vecino, Brozovic, Gabigol, Eder, Jovetic, Pinamonti
Fiorentina: Sportiello; Bruno Gaspar, Vitor Hugo, Astori, Maxi Olivera; Veretout, Sanchez; Gil Dias, Eysseric, Benassi; Simeone
Fiorentina bench: Dragowski, Cerofolini, Tomovic, Pezzella, Milenkovic, Hristov, Biraghi, Badelj, Cristoforo, Zekhnini, Hagi, Babacar