Milan rely on new faces like Franck Kessie, Hakan Calhanoglu and captain Leonardo Bonucci for their trip to Crotone.
It kicks off at 19.45 UK time (18.45 GMT), follow the build-up and action from all eight Serie A games on the LIVEBLOG.
The Rossoneri have already played three competitive games this season, scoring 10 goals and conceding none in the Europa League, including Thursday’s 6-0 thrashing of Shkendija.
Alessio Romagnoli, Jack Bonaventura and Lucas Biglia are injured, while M’Baye Niang, Jose Sosa, Gabriel Paletta (who is suspended too) and Gustavo Gomez are transfer-listed.
Vincenzo Montella rests Andre Silva following his brace against Shkendija, so teenage striker – linked with a loan move to Crotone – Patrick Cutrone is flanked by Suso and Fabio Borini.
Manuel Locatelli steps in for Riccardo Montolivo, joining summer signings Calhanoglu and Kessie.
Bonucci made his competitive debut for Milan on Thursday in Europe and here wears the Rossoneri jersey in Serie A for the first time.
Crotone were the miracle team last season, not just because the tiny Calabrian minnows earned their first ever top-flight campaign, but also fought back from a dismal start to stay up on the final day.
It was between Marco Davide Faraoni and Mario Sampirisi at right-back, while Rolando Mandragora and Barberis were challenging for a midfield spot.
It’s good to see Adrian Stoian back after he was hospitalised with a viral infection in April.
Crotone: Cordaz; Faraoni, Ceccherini, Cabrera, Martella; Rohden, Mandragora, Barberis, Stoian; Trotta, Budimir
Milan: G Donnarumma; Conti, Bonucci, Musacchio, Rodriguez; Kessié, Locatelli, Calhanoglu; Suso, Cutrone, Borini