Roma seem ready to start Bruno Peres and Gregoire Defrel, while Atletico Madrid have two doubts for their Olimpico line-up.
It kicks off at 19.45 UK time (18.45 GMT) at the Stadio Olimpico, the opening Champions League group game.
The Giallorossi are without Emerson Palmieri, Luca Pellegrini, Rick Karsdorp, Patrik Schick and Nura.
Alessandro Florenzi is ready for his comeback after rupturing his ACL twice over the last year, but not from the start, so Peres gets the nod at right-back and Defrel in the trident attack with Edin Dzeko and Diego Perotti.
Roma seem ready to start Bruno Peres and Gregoire Defrel, while Atletico Madrid have two doubts for their Olimpico line-up.
It kicks off at 19.45 UK time (18.45 GMT) at the Stadio Olimpico, the opening Champions League group game.
The Giallorossi are without Emerson Palmieri, Luca Pellegrini, Rick Karsdorp, Patrik Schick and Nura.
Alessandro Florenzi is ready for his comeback after rupturing his ACL twice over the last year, but not from the start, so Peres gets the nod at right-back and Defrel in the trident attack with Edin Dzeko and Diego Perotti.
Atletico Madrid have some concerns going into the game, as Coach Diego Simeone’s line-up could change.
The two issues are to do with right-back, where Juanfran is the favourite over ex-Sassuolo man Sime Vrsaljko, and in attack.
Kevin Gameiro was tested alongside Antoine Griezmann in training and is increasingly likely to start rather than veteran Fernando Torres.
Augusto Fernandez is the only injury absentee.
Probable line-ups
Roma: Alisson; Bruno Peres, Manolas, Juan Jesus, Kolarov; Strootman, De Rossi, Nainggolan; Defrel, Dzeko, Perotti
Atletico Madrid: Oblak; Juanfran, Gimenez, Godin, Filipe Luis; Saul, Gabi, Koke, Carrasco; Griezmann, Gameiro
Ref: Mazic (SRB)