Roma need only a point to be sure of passage to the Champions League Round of 16 as they visit an Atletico Madrid side still without a victory.
It kicks off at the Wanda Metropolitano Stadium at 19.45 GMT.
Follow all the build-up and action as it happens from this game and Juventus-Barcelona on the LIVEBLOG.
Roma need only a point to be sure of passage to the Champions League Round of 16 as they visit an Atletico Madrid side still without a victory.
It kicks off at the Wanda Metropolitano Stadium at 19.45 GMT.
Roma have never beaten Atletico Madrid before, managing just one draw at the Olimpico and two 2-1 defeats in the 1998-99 UEFA Cup quarter-finals.
The Giallorossi would be certain of qualification to the knockout round with a point in Madrid, while Atleti are out of the running if they fail to win.
Alessandro Florenzi, Patrik Schick and Rick Karsdorp are out injured, while Radja Nainggolan is not 100 per cent fit after taking part in the 2-1 Derby della Capitale win over Lazio thanks to painkillers.
Nonetheless, the Belgian starts with Maxime Gonalons and Lorenzo Pellegrini, resting Kevin Strootman and Daniele De Rossi.
Edin Dzeko and Diego Perotti lead the way with Gerson in the trident rather than Stephan El Shaarawy.
Atletico Madrid have won only two of their last 10 competitive games, drawing seven of them, and are without a home victory in five official matches.
Koke made his comeback from a hamstring injury in Saturday’s 0-0 draw with Atletico Madrid and Filipe Luis is also available following a calf problem, but Juanfran is a late addition to the absentee list with a thigh strain.
Because of this, Thomas Partey switches to right-back with Augusto Fernandez in midfield.
Former Fiorentina defender Stefan Savic sits out a ban in defence with Napoli transfer target Sime Vrsaljko sidelined.
Fernando Torres gets the nod in attack along with under-fire Antoine Griezmann, who hasn’t scored in two months and was recently booed by his own fans.
Atletico Madrid: Oblak; Thomas Partey, Gimenez, Lucas Hernandez, Filipe Luis; Koke, Augusto, Saul Niguez, Carrasco; Torres, Griezmann
Atleti bench: Moya, Godin, Correa, Gabi, Vietto, Gameiro, Gaitan
Roma: Alisson; Peres, Manolas, Fazio, Kolarov; Nainggolan, Gonalons, Pellegrini; Gerson, Dzeko, Perotti
Roma bench: Skorupski, Juan Jesus, Moreno, De Rossi, El Shaarawy, Strootman, Defrel
Ref: Kuipers (NED)