Lucas Biglia is the only real decision Milan have to make going into the Derby della Madonnina, but Inter are forced to reshuffle again.
It kicks off at 19.30 GMT, click here for a match preview.
The Rossoneri have practically a full squad at their disposal, save for Giacomo Bonaventura and dropped Riccardo Montolivo.
Mattia Caldara is even back in the side after making his comeback for the Primavera youth team following several months out injured.
Lucas Biglia is the only real decision Milan have to make going into the Derby della Madonnina, but Inter are forced to reshuffle again.
It kicks off at 19.30 GMT, click here for a match preview.
The Rossoneri have practically a full squad at their disposal, save for Giacomo Bonaventura and dropped Riccardo Montolivo.
Mattia Caldara is even back in the side after making his comeback for the Primavera youth team following several months out injured.
Gennaro Gattuso’s starting XI seems in little doubt save for a possible midfield switch, as Biglia impressed so much against Chievo last week that it’s reported he could again replace Tiemoue Bakayoko.
That was the Argentina international’s first start since October.
It is the debut Milan Derby for January buys Lucas Paqueta and Krzysztof Piatek, who made an immediate impact at the club.
Luciano Spalletti is increasingly frustrated at the situation on the black-and-blue side of San Siro, as the injury crisis continues to mount.
After their Europa League exit to Eintracht Frankfurt on Thursday, Inter need to get back on track in Serie A to secure a top four finish.
Joao Mario, Radja Nainggolan, Joao Miranda and of course Mauro Icardi are unavailable, while Marcelo Brozovic needs a fitness test as he recovers from a muscular issue.
If the Croatian doesn’t make it, then Roberto Gagliardini could step in to midfield, with Borja Valero in a more advanced trequartista role.
Lautaro Martinez and Kwadwo Asamoah were able to rest on Thursday, as they were suspended in the Europa League.
Probable line-ups
Milan (4-3-3): G Donnarumma; Calabria, Musacchio, Romagnoli, Rodriguez; Kessie, Bakayoko, Paqueta; Suso, Piatek, Calhanoglu
Inter (4-2-3-1): Handanovic; D’Ambrosio, De Vrij, Skriniar, Asamoah; Vecino, Brozovic; Politano, Borja Valero, Perisic; Lautaro Martinez