Lazio look to field their ideal XI in the Derby della Capitale, but Roma will again be forced into decisions by an injury crisis.
It kicks off at 17.00 GMT, click here for a match preview.
The Aquile are the favourites going into the Stadio Olimpico, as they have won their last 11 Serie A games in a row.
Simone Inzaghi also has a full squad to choose from, as Luis Alberto and Joaquin Correa return from injury and are expected to start.
Lazio look to field their ideal XI in the Derby della Capitale, but Roma will again be forced into decisions by an injury crisis.
It kicks off at 17.00 GMT, click here for a match preview.
The Aquile are the favourites going into the Stadio Olimpico, as they have won their last 11 Serie A games in a row.
Simone Inzaghi also has a full squad to choose from, as Luis Alberto and Joaquin Correa return from injury and are expected to start.
Ciro Immobile is Capocannoniere on 23 goals from only 19 Serie A matches and will be glad to have the top assist man in Serie A back in support.
Danilo Cataldi, Jordan Lukaku and Adam Marusic are the only absentees, but this is essentially Inzaghi’s ideal XI.
The same certainly cannot be said of Roma, who are missing Nicolò Zaniolo, Henrikh Mkhitaryan, Amadou Diawara, Davide Zappacosta and Mirco Antonucci.
Javier Pastore and Diego Perotti are back in the squad, but coach Paulo Fonseca already confirmed in his press conference that they would not be fit to start.
Bryan Cristante therefore should partner Jordan Veretout in midfield, with Cengiz Under, Lorenzo Pellegrini and Justin Kluivert supporting Edin Dzeko.
The only real choices are at full-back, where Leonardo Spinazzola could be used on the right rather than Alessandro Florenzi, even though he is more suited to the left.
Roma: Pau Lopez; Spinazzola, Mancini, Smalling, Kolarov; Cristante, Veretout; Under, Pellegrini, Kluivert; Dzeko
Lazio: Strakosha; Luiz Felipe, Acerbi, Radu; Lazzari, Milinkovic-Savic, Leiva, Luis Alberto, Lulic; Correa; Immobile
Ref: Calvarese