Lazio pick Felipe Caicedo with Ciro Immobile, while Josip Ilicic starts for Atalanta in this showdown for fourth place.
It kicks off at the Stadio Olimpico at 14.00 UK time (13.00 GMT).
You can follow all the action as it happens from today’s six Serie A games on the LIVEBLOG.
These teams will meet here again on May 15 for the Coppa Italia Final, but for now it’s a head-to-head for Champions League football.
Lazio pick Felipe Caicedo with Ciro Immobile, while Josip Ilicic starts for Atalanta in this showdown for fourth place.
It kicks off at the Stadio Olimpico at 14.00 UK time (13.00 GMT).
You can follow all the action as it happens from today’s six Serie A games on the LIVEBLOG.
These teams will meet here again on May 15 for the Coppa Italia Final, but for now it’s a head-to-head for Champions League football.
It’s incredibly tight and a win would even take Atalanta within a point of third-placed Inter.
The Bergamo Boys currently sit in fourth place on 59 points, but Lazio are on 55 in eighth, so the fight for Europe will go down to the wire.
Senad Lulic is suspended with Sergej Milinkovic-Savic, Stefan Radu, Valon Berisha, Patric and Jordan Lukaku injured for Lazio, but Thomas Strakosha starts despite a back problem in training.
With both first choice wingers missing, Simone Inzaghi opts to keep Romulo on the right and move Adam Marusic to the left.
After scoring a brace to beat Sampdoria 2-1 last week, Felipe Caicedo partners Ciro Immobile, sending Joaquin Correa to the bench.
Atalanta miss Rafael Toloi and Musa Barrow, with Robin Gosens not 100 per cent fit, so Timothy Castagne is given the nod on the left flank.
Papu Gomez and Duvan Zapata are eager to get going, but Ilicic skipped the 2-0 win over Udinese with a recurring knee issue and is back in the starting XI for this huge game.
Atalanta need to be careful, as they have several players who are one yellow card away from a Serie A ban: Andrea Masiello, Remo Freuler, Jose Luis Palomino, Hans Hateboer, Gianluca Mancini, Ilicic and Gomez.
Only Bayern Munich (39) and Hoffenheim (38) have more away goals than Atalanta’s 37 in Europe’s top five leagues this season.
Atalanta are unbeaten against Lazio in three Serie A meetings, so a fourth would be their longest streak since 2001.
Lazio: Strakosha; Wallace, Acerbi, Bastos; Romulo, Parolo, Leiva, Luis Alberto, Marusic; Caicedo, Immobile
Atalanta: Gollini; Djimsiti, Palomino, Masiello; Hateboer, Freuler, De Roon, Castagne; Gomez; Ilicic, Duvan Zapata