Tommaso Rocchi takes over from Miroslav Klose as Lazio welcome Cagliari to the Stadio Olimpico.
The Biancocelesti are still hanging on in third place despite two consecutive defeats and an injury crisis.
Klose has been ruled out for a month and misses this game along with Javier Garrido, Senad Lulic and banned duo Andre Dias and Francelino Matuzalem.
Veteran Rocchi returns from his own lay-off to start with support from Hernanes, while Abdoullay Konko gets the nod ahead of Lionel Scaloni in defence.
Lazio Coach Edy Reja is on a touchline ban, so Giovanni Lopez gives the orders.
Cagliari have Michele Canini suspended with Moustafa El Kabir, Daniele Dessena, Rui Sampaio and Sebastian Eriksson injured.
Mauricio Pinilla and Victor Ibarbo start in attack with Andrea Cossu taking the trequartista role, so Thiago Ribeiro is on the bench.
Lazio: Marchetti; Konko, Diakitè, Biava, Radu; Gonzalez, Ledesma, Brocchi; Mauri, Hernanes; Rocchi.
Lazio bench: Bizzarri, Scaloni, Zauri, Cana, Candreva, Kozak, Alfaro
Cagliari: Agazzi; Pisano, Ariaudo, Astori, Agostini; Ekdal, Conti, Nainggolan; Cossu; Ibarbo, Pinilla.
Cagliari bench: Avramov, Bovi, Perico, Gozzi, Nenè, Larrivey, Ribeiro