Juventus have Simone Pepe, Alessandro Matri and Mirko Vucinic leading the line against Inter’s Diego Milito and Diego Forlan.
The old rivals go head-to-head in Turin at 19.45 UK time and Claudio Ranieri faces his former club.
The Bianconeri need a victory to keep up with leaders Milan, but have Stephan Lichtsteiner suspended and Emanuele Giaccherini out with flu symptoms.
Martin Caceres receives a rare start at right-back in place of Lichtsteiner with Andrea Barzagli returning from injury to partner Giorgio Chiellini.
Pepe, Matri and Vucinic retain their places in attack after the Coppa Italia semi-final result against Milan on Tuesday.
Inter miss Wesley Sneijder and Ricky Alvarez for this trip to Turin, where they haven’t won since April 2005.
Milito and Forlan are the front two despite the Uruguayan’s recent poor performances, while andrea Poli and Joel Obi push Esteban Cambiasso on to the bench.
Juventus: 1 Buffon; 4 Caceres, 15 Barzagli, 3 Chiellini, 11 De Ceglie; 22 Vidal, 21 Pirlo, 8 Marchisio, 7 Pepe, 32 Matri, 14 Vucinic
Juventus bench: 30 Storari, 19 Bonucci, 20 Padoin, 34 Marrone, 10 Del Piero, 18 Quagliarella, 23 Borriello
Inter: 1 Julio Cesar; 13 Maicon, 6 Lucio, 23 Samuel, 55 Nagatomo; 4 Zanetti, 5 Stankovic, 18 Poli, 20 Obi; 9 Forlan, 22 Milito.
Inter bench: 12 Castellazzi, 23 Ranocchia, 26 Chivu, 37 Faraoni, 14 Guarin, 19 Cambiasso, 7 Pazzini
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £11,000 to be won monthly!