Andrea Stramaccioni makes his Inter debut and switches to a 4-3-3 formation with Mauro Zarate, Diego Milito and Diego Forlan against Genoa.
He was the Primavera youth team Coach until Monday night, when promoted to replace Claudio Ranieri, becoming their third tactician of the campaign.
Aged 36, Stramaccioni is younger than his own captain, but is without the injured Wesley Sneijder and Douglas Maicon.
The Nerazzurri move to a 4-3-3 system with Zarate given a rare start alongside Forlan and Milito.
Genoa continue to struggle this season and Pasquale Marino missed Kevin Constant, Juraj Kucka, Luca Antonelli and Andreas Granqvist for this trip.
Rodrigo Palacio partners Alberto Gilardino in attack with support from Giuseppe Sculli.
Inter: 1 Julio Cesar; 4 Zanetti, 6 Lucio, 25 Samuel, 26 Chivu; 18 Poli, 5 Stankovic, 19 Cambiasso; 28 Zarate, 22 Milito, 9 Forlan
Inter bench: 12 Castellazzi, 23 Ranocchia, 55 Nagatomo, 14 Guarin, 20 Obi, 7 Pazzini, 88 Livaja
Genoa: 1 Frey; 20 Mesto, 3 Carvalho, 13 Kaladze, 24 Moretti; 88 Biondini, 4 Veloso, 25 Belluschi; 81 Sculli, 82 Gilardino, 8 Palacio
Genoa bench: 22 Lupatelli, 9 Zé Eduardo, 10 Birsa, 11 Jankovic, 18 Alhassan, 19 Jorquera, 21 Bovo