Places in Europe are up for grabs in a head-to-head between Lazio and Inter, but both sides have to reshuffle.
Either team could still qualify for the Champions League, but only if Udinese lose in Catania this evening.
Lazio can get third if Udinese lose and they win, while Inter must hope the Friulani are defeated, they win this match and Napoli fail to beat Siena.
The various stages of Europa League qualification are also up for grabs, as placement can mean the difference between starting the season in early August or going straight into the group phase.
The Biancocelesti must do without Federico Marchetti and Andre Dias due to bans, plus the injured Hernanes, Emiliano Alfaro, Tommaso Rocchi, Stefan Radu, Marius Stankevicius, Cristian Brocchi and Francelino Matuzalem.
Miroslav Klose was a last-minute addition to the injury list, so Libor Kozak is the lone available striker with support from Antonio Candreva, Stefano Mauri and Senad Lulic.
Inter have Julio Cesar suspended, plus Wesley Sneijder, Diego Forlan, Dejan Stankovic, Cristian Chivu, Joel Obi and Luc Castaignos injured. Mauro Zarate is dropped against the club that still owns his contract.
Ricky Alvarez and Fredy Guarin are among those supporting Diego Milito in an unusual new formation.
Lazio: 1 Bizzarri; 5 Scaloni, 21 Diakité, 20 Biava, 29 Konko; 27 Cana, 24 Ledesma; 87 Candreva 6 Mauri, 19 Lulic; 18 Kozak
Lazio bench: 16 Berardi, 14 Garrido, 15 Gonzalez, 28 Makinwa, 41 Zampa, 53 Rozzi, 78 Zauri
Inter: 12 Castellazzi; 13 Maicon, 6 Lucio, 25 Samuel, 55 Nagatomo; 4 Zanetti, 14 Guarin, 19 Cambiasso, 18 Poli, 11 Alvarez; 22 Milito
Inter bench:21 Orlandoni, 2 Cordoba, 23 Ranocchia, 40 Juan, 37 Faraoni, 7 Pazzini, 81 Longo