The Italy Under-21 side has lost Alessandro Crescenzi and Riccardo Saponara for the friendly against Holland.
The Pescara player picked up a muscular problem in his left thigh, while Empoli forward Saponara sprained his right ankle.
The Azzurrini are set to play against their Dutch counterparts on Wednesday August 15.
It will be the debut of new Under-21 Coach Devis Mangia, who already had to make several changes to his squad.
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