Napoli have Lorenzo Insigne and Edinson Cavani against Fiorentina’s Stevan Jovetic and Mounir El Hamdaoui.
Both sides started the campaign with victories and another win here could see them top of the table, but Fiorentina are unbeaten at the San Paolo since 2008.
Goran Pandev and Andrea Dossena complete their two-match bans, but Juan Camilo Zuniga returns to the starting XI after his suspension.
That means Insigne again partners Cavani with Marek Hamsik in a deeper role.
Fiorentina Coach Vincenzo Montella faces his hometown club with a full squad, missing only Francesco Della Rocca.
Transfer deadline day arrivals Luca Toni and Cristian Llama are not included in this trip, but Nenad Tomovic is thrown into the starting XI.
There are concerns over the quality of football that will be on display this evening, as the Stadio San Paolo pitch is in terrible condition.
Napoli:De Sanctis; Campagnaro, Cannavaro, Britos; Maggio, Behrami, Dzemaili, Hamsik, Zuniga; Insigne; Cavani
Fiorentina:Viviano; Roncaglia, Gonzalo Rodriguez, Tomovic; Cuadrado, Romulo, Pizarro, Borja Valero, Pasqual; El Hamdaoui, Jovetic