Juventus boss Antonio Conte is prepared to rest as many as four first team regulars against Genoa ahead of their Champions League campaign.
The Old Lady travel to Marassi on Sunday before then turning their attention to the trip to Chelsea on Wednesday.
Conte, whose side have collected two wins from two this term, is thinking of changes in defence, midfield and attack.
Giorgio Chiellini, despite being fit again, may not be risked in the back-three that could allow Martin Caceres to get a game.
In midfield of the 3-5-2, Chilean international Arturo Vidal and new signing Kwadwo Asamoah could start on the bench.
Meanwhile, Alessandro Matri looks like he will begin instead of Sebastian Giovinco alongside Mirko Vucinic in attack.
Betting on Serie A? Bet365 are offering a 100% deposit bonus, up to £200 - find out more