Napoli look to the Three Tenors for a very difficult trip to face Ciro Ferrara’s unbeaten Sampdoria.
The Partenopei have to win at Marassi to stay joint top of the table after Juventus demolished Roma 4-1 last night.
Walter Mazzarri faces his former club and has only Miguel Angel Britos on the treatment table.
Edinson Cavani scored a hat-trick against Lazio on Wednesday and again starts in Genoa with Goran Pandev and Marek Hamsik.
Ferrara admits this can “never be a game like any other” for the native Neapolitan and former Napoli defender.
Samp are still unbeaten, but have a large absentee list for this very difficult match. Maxi Lopez and Enzo Maresca are suspended, joining the injured Nicola Pozzi, Andrea Poli, Fernando Tissone and Juan Antonio.
It means Roberto Soriano gets a rare chance in attack with Eder and ex-Juventus winger Marcelo Estigarribia.
Sampdoria: Romero; Costa, Gastaldello, Rossini, Berardi; Munari, Krsticic, Obiang; Soriano, Eder, Estigarribia
Sampdoria bench: Berni, Falcone, Mustafi, Poulsen, Castellini, Renan, De Silvestri, Icardi
Napoli: De Sanctis; Campagnaro, Cannavaro, Gamberini; Maggio, Behrami, Inler, Zuniga; Hamsik; Pandev, Cavani
Napoli bench: Rosati, Grava, Aronica, Fernandez, Dzemaili, Mesto, El Kaddouri, Dossena, Insigne, Vargas