Udinese visit Anfield Road with Antonio Di Natale leading a reshuffled side against Fabio Borini’s Liverpool.
The Europa League began with a 1-1 home draw against Anzhi, but the Friulani have won only one game all season against nine-man Milan, so form is not reassuring.
Liverpool have Jonjo Shelvey available, as his ban only applies to domestic games, but Jose Enrique, Martin Kelly and Lucas Leiva are on the treatment table.
Di Natale has missed the last two Udinese matches due to injury and then disciplinary action following a locker room row.
The 34-year-old hitman usually skips European ties, but starts tonight in a new 4-3-3 system with Pablo Armero and Roberto Pereyra advanced from their usual winger roles.
Liverpool: Reina; Johnson, Coates, Carragher, Robinson; Henderson, Allen, Shelvey; Downing, Borini, Assaidi
Liverpool bench: Jones, Skrtel, Wisdom, Nuri Sahin, Gerrardo, Sterling, Suarez
Udinese: Brkic; Benatia; Danilo, Domizzi; Faraoni, Badu, Pinzi, Pasquale; Pereyra, Di Natale, Armero
Udinese bench: Padelli, Coda, Heurteaux, Lazzari, Willians, Ranegie, Fabbrini