Fabrizio Miccoli leads Palermo out at Marassi as former Genoa boss Gian Piero Gasperini returns to his old club.
Gasp has not stepped back into the Stadio Luigi Ferraris since leaving Genoa in 2010 and took over the Rosanero bench in Week 4.
Miccoli is fired up and raring to go after scoring a sensational hat-trick against Chievo last weekend, though Franco Brienza is suspended.
Andrea Mantovani joins Eran Zahavi and Milan Milanovic on the injury list, so Luigi Giorgi starts with Massimo Donati again redirected to centre-back.
Genoa are eager to get a strong result in front of the home fans, though Marco Rossi and Damiano Ferronetti are sidelined.
Juan Manuel Vargas returns to the squad, although he is only fit for the bench, while Felipe Seymour and Bosko Jankovic are preferred to Cristobal Jorquera and Andrea Bertolacci.
Ciro Immobile and Marco Borriello again form the strike partnership.
Genoa: Frey; Bovo, Granqvist, Sampirisi, Antonelli; Kucka, Tozser, Seymour; Jankovic, Borriello, Immobile
Palermo: Ujkani; Munoz, Donati, Von Bergen; Morganella, Rios, Barreto, Garcia; Ilicic, Giorgi; Miccoli