The Derby della Madonnina is a huge test for two teams in the balance and sees Antonio Cassano take on Milan, but Bojan Krkic is preferred to Giampaolo Pazzini.
The massive match kicks off at San Siro at 19.45 BST and remember you can watch LIVE on your computer.
Inter are higher up the table and have improved since adopting the new three-man defence, but Wesley Sneijder, Cristian Chivu, Dejan Stankovic and MacDonald Mariga are out of action.
Cassano starts against the club he left in pretty tense circumstances over the summer, exchanging places with Pazzini.
He partners Diego Milito with support from Philippe Coutinho.
The Rossoneri have stuttered this season, but are fresh from a 3-2 Champions League victory away to Zenit on Wednesday.
Alexandre Pato, Sulley Muntari, Didac Vila, Djamel Mesbah and Rodney Strasser are sidelined.
Daniele Bonera and Mattia De Sciglio are picked as the full-backs, leaving out Luca Antonini and Ignazio Abate.
Milan: 32 Abbiati; 25 Bonera, 76 Yepes, 5 Mexes, 2 De Sciglio; 34 De Jong, 18 Montolivo; 28 Emanuelson, 10 Boateng, 92 El Shaarawy; 22 Bojan
Milan bench: 1 Amelia, 59 Gabriel, 7 Robinho, 8 Nocerino, 11 Pazzini, 13 Acerbi, 16 Flamini, 17 Zapata, 20 Abate, 21 Costant, 23 Ambrosini, 77 Antonini
Inter: 1 Handanovic; 23 Ranocchia, 25 Samuel, 40 Juan Jesus; 4 Zanetti, 21 Gargano, 19 Cambiasso, 55 Nagatomo; 7 Coutinho; 99 Cassano, 22 Milito
Inter bench: 12 Castellazzi, 27 Belec, 6 Silvestre, 8 Palacio, 14 Guarin, 16 Mudingayi, 20 Obi, 31 Pereira, 41 Duncan, 42 Jonathan, 44 Bianchetti, 88 Livaja
Tickets for the Champions League final between Juventus and Real Madrid are still on sale with reseller Viagogo - Click to find out more