It’s bound to be an exhilarating encounter as Edinson Cavani’s Napoli take on Antonio Di Natale’s Udinese.
This is one of two 19.45 BST kick-offs tonight and remember you can watch LIVE on your computer.
The Partenopei need to get back on track after a 3-0 hammering to PSV in the Europa League on Thursday evening.
Miguel Angel Britos is injured and Paolo Cannavaro suspended, so Federico Fernandez steps into the back three.
Cavani is partnered by Goran Pandev with Marek Hamsik in a deeper role this season, while Gokhan Inler faces his former teammates.
Udinese earned an historic 3-2 victory over Liverpool at Anfield Road this week, despite an injury list that includes Luis Muriel, Dusan Basta and Emmanuel Badu.
Native Neapolitan Di Natale leads the way at the San Paolo, always a special game for the hitman, but he is surprisingly partnered by Brazilian Maicosuel.
Napoli: De Sanctis; Campagnaro, Fernandez, Gamberini; Maggio, Inler, Behrami, Hamsik, Zuniga; Pandev; Cavani
Napoli bench: Rosati, Grava, Aronica, Uvini, Mesto, El Kaddouri, Dzemaili, Donadel, Dossena, Insigne, Vargas
Udinese: Brkic; Benatia, Danilo, Domizzi; Pereyra, Allan, Pinzi, Lazzari, Pasquale; Maicosuel, Di Natale
Udinese bench: Padelli, Pawlowski, Coda, Angella, Willians, Heurteaux, Armero, Barreto, Faraoni, Ranegie, Fabbrini