Lazio boss Vladimir Petkovic is the latest Serie A tactician to consider the use of a 3-5-2 formation.
A host of outfits in the top flight now use that system and the Bosnian tried out the shape in a 6-2 friendly win over Civitavecchia.
Giuseppe Biava, Andre Dias and Michael Ciani were used as the three centre-backs in the game ahead of the Milan clash on October 20.
Meanwhile, Stefan Radu returned to action in the same tie after knee surgery. The Romanian has been sidelined with one injury or another since the April 7 game against Napoli.
Lazio, currently joint third in the table, have successfully used a 4-1-4-1 system this term.