Roma-Palermo looks like a guarantee for goals, while Napoli, Lazio and Fiorentina must fight past tricky customers to keep up the title pace.
The lunch-time kick-off at 11.30am GMT is a last chance saloon for Giovanni Stroppa’s Pescara against Parma.
Also expect tense relegation dogfights in Genoa and Siena.
Click here for all the individual match previews plus reports from Saturday’s Milan-Chievo and Juventus-Inter.
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition - £10,000 to be won!