The Derby della Capitale is all about attack, as Francesco Totti, Erik Lamela and Pablo Daniel Osvaldo take on Hernanes and Miroslav Klose, but Daniele De Rossi moves.
This fixture is always a huge occasion, but this time it’s sure to be a feast of football for the neutrals too, as there are two points between these prolific teams.
Zdenek Zeman’s Roma remain thrilling and inconsistent, even during the space of 90 minutes, but seem to have found their feet with a series of high-scoring wins.
Mattia Destro is suspended, while Bogdan Lobont and Maarten Stekelenburg are injured, but the attacking trio remains Totti-Osvaldo-Lamela.
Having refused to use De Rossi in a central midfield role so far this season, Zeman does re-route the Italian international in place of Panagiotis Tachtsidis.
Lazio have had an intense week, going from a 4-0 defeat in Catania to 3-0 Europa League win over Panathinaikos.
Ederson and Giuseppe Sculli are the only absentees, as Klose leads the way with support from Hernanes, Stefano Mauri and Antonio Candreva.
Senad Lulic and Federico Marchetti also made their comebacks midweek.
Lazio: Marchetti; Konko, Biava, Dias, Lulic; Ledesma; Candreva, Gonzalez, Hernanes, Mauri; Klose
Lazio bench: Bizzarri, Radu, Scaloni, Ciani, Cavanda, Brocchi, Cana, Onazi, Zarate, Floccari, Kozak, Rocchi
Roma: Goicoechea; Piris, Marquinhos, Burdisso, Balzaretti; Bradley, De Rossi, Florenzi; Lamela, Osvaldo, Totti
Roma bench: Svedkauskas, Castan, Romagnoli, Taddei, Dodo, Pjanic, Tachtsidis, Marquinho, Perrotta, Lopez