The Marassi match will go ahead despite flood warnings, as Neapolitan Ciro Immobile takes on his hometown club with Edinson Cavani on stunning form.
There were fears the game would have to be called off after a storm swept in and put the city of Genoa on lockdown, as the weather front is a knock-on effect from Hurricane Sandy.
However, the city has held up well and so has the pitch at the Stadio Luigi Ferraris, commonly known as Marassi.
Gigi Del Neri is feeling the pressure after losing all three of his games on the Genoa bench and the injury crisis still has Juan Manuel Vargas, Cristobal Jorquera, Damiano Ferronetti and Anselmo unavailable.
Marco Borriello is a shock inclusion on the bench despite being ruled out for six weeks by a sprained ankle, while Cesare Bovo is suspended.
Napoli need to get back on track in Serie A after losing second place and gifting Torino a point last week with Salvatore Aronica’s last-gasp howler.
Cavani is on fire after scoring four in Thursday’s 4-2 win over Dnipro in the Europa League and starts again.
Juan Camilo Zuniga is the only absentee for Walter Mazzarri.
Genoa: Frey; Sampirisi, Granqvist, Moretti, Antonelli; Canini, Toszer, Kucka; Bertolacci, Immobile, Jankovic
Napoli: De Sanctis; Campagnaro, Cannavaro, Gamberini; Maggio, Behrami, Dzemaili, Dossena; Hamsik; Pandev, Cavani