Antonio Di Natale makes a rare Europa League start with Diego Fabbrini as Udinese visit Anzhi with Samuel Eto’o at 17.00 GMT.
The Friulani had been top of Group A, but back-to-back defeats against Young Boys saw them plummet to the bottom and chances of qualification are very slim indeed.
Nonetheless, Francesco Guidolin is pulling out all the stops with Di Natale starting alongside Under-21 international Fabbrini, though there are changes elsewhere with Thomas Heurtaux getting a rare start.
Russian side Anzhi drew 1-1 at the Stadio Friuli when these sides met in the first round and again look to talisman Eto’o to lead the way.
Anzhi have an excellent home record in the Europa League, winning all five home games without conceding a goal.
Anzhi: V Gabulov; Logashov, Samba, Joao Carlos, Tagirbekov; Shatov, Jucilei; Carcela-Gonzalez, Boussoufa, Zhirkov; Eto’o
Anzhi bench: Pomazan, Gadzhibekov, Agalarov, Lahiyalov, Muhammad, Traore, Burmistrov
Udinese: Brkic; Heurtaux, Danilo, Domizzi; Faraoni, Willians, Badu, Pereyra, Armero; Di Natale, Fabbrini
Udinese bench: Padelli, Basta, Coda, Pasquale, Reinthaler, Ranegie, Marsura
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £11,000 to be won monthly!