Lazio look to Libor Kozak, Stefano Mauri and Hernanes as they welcome Gareth Bale’s Tottenham to the Stadio Olimpico.
The Biancocelesti are currently leaders of their Europa League group and will secure the top spot if they manage to win this evening, kick-off at 18.00 GMT.
Miroslav Klose is out injured, so Kozak is chosen after his brace against Panathinaikos, backed by Mauri, Hernanes and Alvaro Gonzalez, but Antonio Candreva is rested.
Tottenham are under pressure after a poor run of results in the Premier League and Europe, having drawn both their away games 1-1 in Group J.
Bale is the star man, while Clint Dempsey and Emmanuel Adebayor lead the front line.
Lazio: Marchetti; Cavanda, Biava, Ciani, Radu; Mauri, Gonzalez, Ledesma, Hernanes, Lulic; Kozak
Lazio bench: Bizzarri, Scaloni, Ederson, Onazi, Candreva, Rozzi, Floccari
Tottenham: Lloris; Walker, Caulker, Vertonghen, Naughton; G Sigurdsson, Sandro, Carroll, Bale; Dempsey, Adebayor
Tottenham bench: Cudicini, Dawson, Huddlestone, Lennon, Dembele, Livermore, Defoe