Zdenek Zeman returns to face his beloved Pescara on his 100th Roma match, as Mattia Destro takes on debutant Coach Cristiano Bergodi.
ZZ took the Delfini to promotion from Serie B last season with his thrilling 4-3-3 approach, but the club has not fared well so far without him.
Giovanni Stroppa resigned last week and former Modena and Cluj boss Bergodi here makes his Serie A debut on the bench.
He has to do without the suspended Damiano Zenon, Marco Capuano and Emmanuel Cascione, while Giuseppe Colucci and Manuele Blasi are injured.
Zeman marks his 100th official match on the Roma bench, spread out over two spells from 1997-99 and the current campaign.
Daniele De Rossi continues to sit out his three-match ban, joined by the injured Erik Lamela, Rodrigo Taddei and Maarten Stekelenburg.
It means Destro receives a rare start in attack with Francesco Totti and Pablo Daniel Osvaldo.
Miralem Pjanic steps in to De Rossi’s midfield boots with Michael Bradley and Alessandro Florenzi.
Pescara: Perin; Romagnoli, Terlizzi, Bocchetti; Balzano, Bjarnason, Nielsen, Togni, Modesto; Quintero, Abbruscato
Pescara bench: Pelizzoli, Cosic, Crescenzi, Vukusic, Soddimo, Brugman, Weiss, Caprari, Celik, Jonathas
Roma: Goicoechea; Piris, Marquinhos, Castan, Balzaretti; Pjanic, Bradley, Florenzi; Destro, Osvaldo, Totti
Roma bench: Lobont, Svedkauskas, Burdisso, Dodò, Marquinho, Tachtsidis, Romagnoli, Perrotta, Lopez