Gian Piero Gasperini returns to San Siro with Palermo seeking revenge on Inter, while Vincenzo Montella, Lorenzo Insigne and Mattia Destro also face their past.
Click here for all the individual match previews, plus reports from the Turin Derby and Catania-Milan.
The day kicks off at 11.30am GMT with Napoli welcoming Pescara to the San Paolo, then all eyes will be on Gasperini a year after he was sacked by Inter.
Roma striker Destro looks set to take centre stage in Siena, while Gigi Del Neri also takes on his past as Chievo visit Genoa.
Lazio hope to get the better of giant-killers Parma and the day is rounded out by revelations Fiorentina taking on Sampdoria, where Coach Montella was a star striker.