Fiorentina are forced to field an all-new front line, as they must beat Sampdoria to recapture third place.
The Viola saw their run of five consecutive victories end with a 2-2 draw at Torino last week.
However, going into this match Luca Toni, Adem Ljajic and Stevan Jovetic are all unavailable due to injury.
This striker shortage has prompted Coach Vincenzo Montella – who spent three years of his playing career at Sampdoria – to choose Mounir El Hamdaoui and Mati Fernandez in attack.
Alberto Aquilani and Michele Camporese are also out of action for the hosts, so Romulo steps into the midfield.
Samp too have a problem picking forwards, as Nicola Pozzi, Maxi Lopez and Eder are sidelined.
Defender Andrea Costa is suspended, while goalkeeper Sergio Romero is in Argentina due to a family matter, so Da Costa takes the gloves.
Therefore teenage hitman Mauro Icardi again leads the front line with support from Nenad Krsticic and Andrea Poli.
Fiorentina: Viviano; Savic, Rodriguez, Tomovic; Cuadrado, Romulo, Pizarro, Borja Valero, Pasqual; Mati Fernandez, El Hamdaoui
Fiorentina bench: Neto, Hegazi, Roncaglia, Olivera, Aquilani, Lupatelli, Cassani, Seferovic, Della Rocca, Llama, Migliaccio, Zohore
Sampdoria: Da Costa; Mustafi, Gastaldello, Rossini, Berardi; Tissone, Maresca, Obiang; Krsticic, Icardi, Poli
Sampdoria bench: Berni, Estigarribbia, Renan, Castelini, Munari, Poulsen, De Silvestri, Soriano, Juan Antonio, Austoni, Falcone