Second-placed Napoli visit Inter in third for a Scudetto clash, while Juventus welcome back Antonio Conte in their tricky trip to Palermo.
Milan face the threat of snow and an icy reception at Torino, but there are relegation dogfights in Siena, Cagliari and Pescara.
The action continues on Monday evening with Sampdoria-Udinese and Bologna-Lazio.
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