Udinese have made five changes from the side that lost to Liverpool in the Europa League, with Antonio Di Natale returning to face Sampdoria.
The Italy international starts up front on his own as the Zebrette look to move into the top half with a win.
Elsewhere, Zelijko Brkic comes in between the posts, replacing Daniele Padelli after their 1-0 defeat at the hands of the Premier League side on Thursday.
For Ciro Ferrara's side, they have opted for a 4-5-1 formation, with Mauro Icardi leading the line, hoping for the three points that would also take them into 10th place.
Sampdoria: Romero; Berardi, Gastaldello, Rossini, Costa; Soriano, Tissone, Maresca, Obiang, Poli; Icardi
Udinese: Brkic; Heurtaux, Danilo, Angella; Basta, Pinzi, Allan, Badu, Pasquale; Pereyra; Di Natale