Stevan Jovetic is back from the start with Luca Toni, but Emiliano Viviano is benched as Fiorentina welcome Siena in the Tuscan Derby.
The clash kicks off at 11.30am GMT in Florence and sees big changes for the Viola.
Jovetic returns for his first game in a month, partnered by Toni, while David Pizarro is back in midfield after compassionate leave.
Goalkeeper Viviano had been carrying a knock to the hip, but was also under fire due to poor form, so he is replaced by Neto.
Juan Cuadrado and Ruben Olivera sit out bans, while Michele Camporese is injured, so Romulo steps in.
Siena go into the game without Ze Eduardo and Andrea Campagnolo, so give a rare start to Marcelo Larrondo.
The striker had been ruled out for three months and 20 days by a ban in the betting scandal and here partners Emanuele Calaiò.
Matteo Rubin is given the nod on the wing instead of Cristiano Del Grosso.
Fiorentina: Neto; Rodriguez, Roncaglia, Savic; Romulo, Aquilani, Pizarro, Borja Valero, Pasqual; Toni, Jovetic
Fiorentina bench: Viviano, El Hamdaoui, Lupatelli, Fernandez, Cassani, Seferovic, Della Rocca, Llama, Migliaccio, Ljajic, Madrigali, Tomovic
Siena: Pegolo; Neto, Paci, Felipe; Angelo, Vergassola, Bolzoni, Rubin; Rosina; Calaiò, Larrondo
Siena bench: Farelli, Marini, Del Grosso, Coppola, Valiani, Verre, Belmonte, Ribair, Contini, Sestu, Reginaldo