The lunch-time kick-off sees Inter welcome Genoa to San Siro, so Diego Milito, Antonio Cassano and Rodrigo Palacio start, but Marco Borriello is dropped after a row.
A packed day of Serie A action begins at 11.30am GMT at the Stadio Giuseppe Meazza.
The Nerazzurri aim to get back on track after a defeat to Lazio left them seven points adrift of leaders Juventus.
Yuto Nagatomo and Luca Castellazzi picked up injuries in the midweek 2-0 Coppa Italia win over Hellas Verona, joining Dejan Stankovic, Joel Obi and Gaby Mudingayi on the treatment table.
Fredy Guarin sits out a ban for insulting the officials.
Andrea Stramaccioni unleashes the 3-4-3 formation with Cassano joining ex-Genoa stars Palacio and Milito.
Genoa are in crisis and have managed only a win, a draw and seven defeats under Coach Gigi Del Neri.
Borriello is sensationally not even on the bench after reports of a blazing row with director of sport Rino Foschi yesterday.
To make matters worse, Emiliano Moretti and Felipe Seymour are suspended, while Cesare Bovo, Cristobal Jorquera and Bosko Jankovic are injured.
Ciro Immobile is the lone striker with support from Andrea Bertolacci and Juan Manuel Vargas.
Inter: Handanovic; Ranocchia, Samuel, Juan Jesus; Zanetti, Gargano, Cambiasso, Alvarez; Cassano, Palacio, Milito
Inter bench: Belec, Di Gennaro, Silvestre, Mariga, Benassi, Chivu, Pereira, Jonathan, Bessa, Livaja
Genoa: Frey; Sampirisi, Canini, Granqvist, Antonelli; Tozser; Rossi, Kucka, Bertolacci, Vargas; Immobile
Genoa bench: Tzorvas, Melazzi, Kranjinic, Hallenius, Piscitella, Marchiori, Said, Al Hassan, Donnarumma, Anselmo
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £11,000 to be won monthly!