Inter hope to end their crisis, but welcome giant-killers Pescara to San Siro amid numerous injury and suspension problems with a Serie A debutant in the starting XI.
The Nerazzurri are struggling of late and the 3-0 thrashing by Udinese last week left them with one point from the last three rounds.
Andrea Ranocchia and Juan Jesus are both suspended, while Walter Samuel, Dejan Stankovic, Luca Castellazzi, Ricky Alvarez and Yuto Nagatomo are injured.
Walter Gargano, Diego Milito, Gaby Mudingayi and MacDonald Mariga are also not 100 per cent fit, so 18-year-old Marco Benassi is given his Serie A debut.
The teenage midfielder has never previously played in the top flight, though he did appear in two Europa League games.
Matias Silvestre is also given a rare chance in defence with Esteban Cambiasso and Cristian Chivu.
Pescara starlet Juan Fernando Quintero is on international duty at the Under-20 tournament in South America, while Togni is suspended.
Uros Cosic is injured, while captain Emmanuel Cascione is only fit for the bench after suffering from toothache.
The Delfini have won two of their last three games, most notably causing a huge upset with last week’s 2-0 victory in Florence.
That result ended Fiorentina’s unbeaten home record and saw one of the performances of the season from goalkeeper Mattia Perin.
It is reported that PSG star Marco Verratti will be in the stands this evening to cheer on his former teammates.
Inter: Handanovic; Silvestre, Cambiasso, Chivu; Jonathan, Zanetti, Benassi, Pereira; Guarin; Cassano, Palacio
Inter bench: Belec, Di Gennaro, Coutinho, Mudingayi, Mariga, Rocchi, Obi, Gargano, Milito, Duncan, Bianchetti, Livaja
Pescara: Perin; Balzano, Capuano, Terlizzi, Modesto; Nielsen, Colucci, Bjarnason; Weiss; Jonathas, Celik
Pescara bench: Pelizzoli, Falso, Zanon, Cascione, Romagnoli, Abbruscato, Bocchetti, Vukusic, Blasi, Caprari