Juventus aim to end Parma’s unbeaten home record, Milan visit giant-killers Sampdoria, Napoli face their Palermo past and Roma clash with Catania.
Click here for all the individual match previews, plus reports from Saturday's Bologna-Chievo and Inter-Pescara.
It’s an action-packed day in Serie A, starting at 11.30am GMT with the Torino-Siena relegation tussle.
This afternoon Lazio hope to beat Atalanta and close further on leaders Juve, while Fiorentina attempt to get back on track at the Friuli.
This evening Sampdoria want to cause another huge upset when they welcome Milan to Marassi.