It’s Antonio Di Natale and Luis Muriel against Stevan Jovetic and Adem Ljajic at the Stadio Friuli.
These sides started 2013 in very different ways, as Udinese hammered Inter 3-0, while Fiorentina lost their unbeaten home record to minnows Pescara.
David Pizarro is unable to face his former club due to injury, while Ruben Olivera is suspended, so Giulio Migliaccio starts in midfield.
Udinese have to do without Mehdi Benatia and Emmanuel Badu due to the African Cup of Nations.
Di natale is supported by Colombian talent Muriel.
This fixture last ended in a draw back in 2006, followed by five home wins and one away.
Udinese: Brkic; Heurtaux, Danilo, Domizzi; Basta, Pereyra, Pinzi, Lazzari, Pasquale; Muriel; Di Natale
Udinese bench: Padelli, Pawloski, Marques, Angella, Faraoni, Coda, Fabbrini, Antunes, Merkel, Maicosuel
Fiorentina: Neto; Savic, Rodriguez, Tomovic; Cuadrado, Borja Valero, Aquilani, Migliaccio, Pasqual; Ljajic, Jovetic
Fiorentina bench: Viviano, Lupatelli, Roncaglia, Seferovic, Llama, Toni, Romulo
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £5,000 monthly.