Napoli have a fantastic opportunity to close the gap on leaders Juventus, but face a Parma side that is still unbeaten at the Tardini.
On Saturday Juve were held by Genoa and Lazio fell at home to Chievo, so the Partenopei can break clear in second place.
Paolo Cannavaro returns for his first match since the six-month ban in the betting scandal was quashed on appeal and does so against his former club.
Valon Behrami is suspended, while Christian Maggio misses out after undergoing surgery for a fractured hand.
Edinson Cavani leads the way with Goran Pandev and Marek Hamsik, while Giandomenico Mesto comes in for Maggio.
Parma are the only side without a home defeat this season and are run by ex-Napoli Coach Roberto Donadoni.
Jonathan Biabiany, Ishak Belfodil and Nicola Sansone form the Ducali trident.
Parma (4-3-3): Mirante; Rosi, Santacroce, Paletta, Gobbi; Marchionni, Valdes, Parolo; Biabiany, Belfodil, Sansone
Parma bench: Pavarini, Bajza, Morrone, Lucarelli, Amauri, Strasser, Palladino, Benalouane, Fideleff, Ninis, Pabon
Napoli (3-4-1-2): De Sanctis; Campagnaro, Cannavaro, Britos; Mesto, Dzemaili, Inler, Zuniga; Hamsik; Pandev, Cavani
Napoli bench: Rosati, Colombo, Grava, Fernandez, Gamberini, Uvini, Donadel, El Kaddouri, Armero, Calaiò, Insigne