Inter give new buys Ezequiel Schelotto and Zdravko Kuzmanovic their debuts, while Fredy Guarin starts despite an injury scare in Siena.
The Nerazzurri are short on confidence after scraping a point against Torino last week, meaning they have won just one of their last four games.
Diego Milito, Esteban Cambiasso, Walter Samuel, Dejan Stankovic, Luca Castellazzi and Gaby Mudingayi are out of action.
Guarin was a late scare, as he picked up a muscular problem in this morning’s training session, but has been given the all-clear to start.
Schelotto and Kuzmanovic only completed their transfers from Atalanta and Stuttgart on transfer deadline day, but are thrown straight into the starting XI, while Mateo Kovacic is on the bench.
Siena continue to prop up the Serie A table and are still without January buy Nicola Pozzi, so new buy Emeghara and Alessandro Rosina lead the way.
Siena: Pegolo; Belmonte, Paci, Felipe; Angelo, Vergassola, Della Rocca, Rubin; Rosina, Sestu; Emeghara
Siena bench: Farelli, Uvini, Valiani, Paolucci, Verre, Agra, Bolzoni, Mannini, Bogdani, Teixeira, Terlizzi, Reginaldo
Inter: Handanovic; Ranocchia, Chivu, Juan Jesus; Schelotto, Kuzmanovic, Zanetti, Nagatomo; Guarin; Cassano, Palacio
Inter bench: Belec, Di Gennaro, Silvestre, Kovacic, Alvarez, Rocchi, Gargano, Benassi, Pereira, Jonathan