Angelo Palombo has not recovered in time for Sampdoria’s trip to Napoli on Sunday afternoon.
The captain, who spent most of his career in midfield and has been revitalised as a centre-back, is not even in the squad.
Eder has returned after he was given compassionate leave in Brazil last week.
Sampdoria squad for Napoli: Berni, Da Costa, Romero; Berardi, Castellini, Costa, De Silvestri, Gastaldello, Mustafi, Poulsen, Rodríguez, Rossini; Krsticic, Maresca, Munari, Obiang, Poli, Soriano; Eder, Estigarribia, Icardi, Maxi Lopez, Sansone
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £11,000 to be won monthly!