Milan are expected to line-up with a flexible 4-3-3, in which Kevin Prince Boateng will be used as a right-sided attacker, against Barcelona this evening.
The Ghanaian, who can also play as a trequartista in a 4-3-1-2, will form a trident attack alongside Giampaolo Pazzini and Stephan El Shaarawy.
Cristian Zapata and Philippe Mexes will start in the middle of the defence, while the midfield may consist of Massimo Ambrosini, Riccardo Montolivo and Sulley Muntari.
Mario Balotelli, signed from Manchester City in January, is Cup-tied.
Milan (4-3-3): Abbiati; Abate, Mexes, Zapata, Constant; Montolivo, Ambrosini, Muntari; Boateng, Pazzini, El Shaarawy.
Substitutes: Amelia, Yepes, De Sciglio, Cristante, Traoré, Bojan, Niang.
Barcelona (4-3-3): Valdes; Dani Alves, Piqué, Puyol, Jordi Alba; Xavi, Busquets, Fabregas; Pedro, Messi, Iniesta.
Substitutes: Pinto, Montoya, Mascherano, Song, Thiago, Sanchez, Tello.