Lazio could be up for another thriller as they welcome Borussia Monchengladbach a week after their 3-3 draw.
The first leg of their Round of 32 Europa League tie was a spectacular six-goal game in Germany and the teams face off again at the Stadio Olimpico at 18.00 GMT.
Andre Dias was sent off in that game after giving away two penalties, so is suspended in Rome, while Miroslav Klose, Stefano Mauri and Cristian Brocchi are injured.
Vladimir Petkovic is taking no chances and using a first choice XI, but drops the 3-5-2 system that crumbled 3-0 to Siena on Monday evening.
Michael Ciani is also dropped in favour of Lorik Cana at centre-back.
Borussia Monchengladbach again look to Luuk De Jong, Patrick Herrmann and Juan Arango in a 4-3-3 approach.
Lazio: Marchetti; Konko, Biava, Cana, Radu; Ledesma; Candreva, Gonzalez, Hernanes, Lulic; Floccari
Lazio bench: Bizzarri, Ciani, Pereirinha, Ederson, Onazi, Kozak, Lombardi
Borussia Monchengladbach: Ter Stegen; Jantschke, Stranzl, Alvaro Dominguez, Wendt; Cigerci, Marx, Nordtveit; Herrmann, De Jong, Arango
Borussia bench: Heimeroth, Daems, Brouwers, Rupp, Xhaka, Hanke, Younes