Inter visit Romania and look to Mateo Kovacic, Rodrigo Palacio and Antonio Cassano in order to reach the Final 16 of the Europa League.
The Nerazzurri won the first leg 2-0 at San Siro and take to the field at 18.00 GMT.
Coach Andrea Stramaccioni may have been tempted to rotate the squad ahead of Sunday’s Milan Derby, but injuries and cup-tied players limit his options.
Palacio and Cassano start in attack with support from Ricky Alvarez and Kovacic, while Javier Zanetti starts at right-back.
Romanian defender Cristian Chivu is on the bench and hopes to play in the second half in his home country.
Cluj have Juventus youth academy product Felice Piccolo in defence, while Rui Pedro and Robert Maah lead the attack, as Gabriel Muresan sits between the lines.
Cluj: Mario Felgueiras; Cadu, Piccolo, Rada; Ivo Pinto, Sepsi, Godemeche, Camora; Muresan; Rui Pedro, Maah
Cluj bench: Stancioiu, Mattei, Diogo Valente, Hora, Celestino, Kapetanos, Bjelanovic
Inter: Handanovic; Zanetti, Ranocchia, Juan, Alvaro Pereira; Guarin, Cambiasso, Kovacic, Alvarez; Palacio, Cassano
Inter bench: Belec, Chivu, Mbaye, Gargano, Benassi, Pasa, Terrani