Napoli will attempt to fight back from a 3-0 first leg defeat with Lorenzo Insigne, Goran Pandev and Emanuele Calaiò away to Viktoria Plzen.
The Partenopei suffered a shock home loss and will need a miracle to turn this Europa League Round of 32 tie around.
Marek Hamsik misses out due to illness, while players like Edinson Cavani, Hugo Campagnaro, Gokhan Inler and Paolo Cannavaro are rested.
However, Coach Walter Mazzarri looks set to switch over to a 4-3-3 system with Christian Maggio and Juan Camilo Zuniga as full-backs.
Viktoria Plzen will be brimming with confidence after their first leg victory and look to Marek Bakos at the front of a 4-2-3-1 line-up.
Viktoria Plzen: Kozacik; Reznik, Cisovsky, Prochazka, Limbersky; Darida, Horvath; Rajtoral, Kolar, Kovarik; Bakos
Plzen bench: Pavlik, Hejda, Zeman, Stipek, Tecl, Fillo, Duris
Napoli: De Sanctis; Maggio, Gamberini, Rolando, Zuniga; Dzemaili, Donadel, Behrami; Pandev, Calaiò, Insigne
Napoli bench: Rosati, Campagnaro, Cannavaro, El Kaddouri, Mesto, Inler, Cavani