Inter go to Catania without Antonio Cassano in a battle for Europe, while Roma aim to end Genoa’s revival this evening.
Click here for all the individual match previews, including reports from Napoli-Juventus and Milan-Lazio.
The action starts at 11.30am GMT when Torino welcome Palermo, who have Gian Piero Gasperini back on the bench a month after he was sacked.
There are also relegation dogfights in Pescara, Siena and Bologna, while Fiorentina need to prove themselves against Chievo.
Betting on Serie A? Bet365 are offering a 100% deposit bonus, up to £200 - find out more