Inter are forced to reshuffle after the Antonio Cassano row, so Tommaso Rocchi starts in their head-to-head for Europe with high-flying Catania.
Click here for a match preview, as only two points separate these teams going into the Stadio Massimino.
Cassano was sensationally dropped after he had a blazing row with Coach Andrea Stramaccioni in the Inter locker room on Friday.
With Diego Milito, Walter Samuel, Matias Silvestre, Yuto Nagatomo, Gaby Mudingayi, Joel Obi and Luca Castellazzi injured, there are few options available.
To make matters worse, Andrea Ranocchia is suspended for the trip to Sicily.
It means veteran Rocchi has to get his first Inter start, as Rodrigo Palacio is not 100 per cent fit either.
He is flanked by Ezequiel Schelotto and Ricky Alvarez in a new 4-3-3 formation.
Catania are on fine form, particularly at home, but have Nicola Legrottaglie and Giuseppe Bellusci banned for this game.
Pablo Barrientos and Ciro Capuano are injured, but Lucas Castro completes the trident attack with Papu Gomez and Gonzalo Bergessio.
Catania: 21 Andujar; 22 Alvarez, 3 Spolli, 5 Rolin, 12 Marchese; 27 Biagianti, 10 Lodi; 13 Izco, 19 Castro, 17 Gomez; 9 Bergessio
Catania bench: 1 Frison, 2 Potenza, 18 Augustyn, 4 Almiron, 8 Sciacca, 24 Ricchiuti, 26 Keko, 30 Salifu, 32 Cani, 34 Messina, 35 Doukara
Inter: 1 Handanovic; 4 Zanetti, 26 Chivu, 40 Juan Jesus, 31 Pereira; 14 Guarin, 17 Kuzmanovic, 21 Gargano; 7 Schelotto, 18 Rocchi, 11 Alvarez
Inter bench: 30 Carrizo, 77 Di Gennaro, 28 Pasa, 33 Mbaye, 42 Jonathan, 5 Stankovic, 10 Kovacic, 19 Cambiasso, 24 Benassi, 8 Palacio, 47 Colombi