Roma welcome back Francesco Totti seeking a record as they try to end Genoa’s unbeaten run under Davide Ballardini.
The Stadio Olimpico hosts the evening game, which kicks off at 19.45 GMT. Click here for a match preview.
Aurelio Andreazzoli has taken the Giallorossi to two consecutive victories and claims Europe is still within reach.
Totti and Daniele De Rossi return from suspension, but Marquinhos has failed a late fitness test, joining Leandro Castan and Mattia Destro on the treatment table.
Instead, Roma give 18-year-old Alessio Romagnoli his first Serie A start in a three-man defence.
Erik Lamela joins Pablo Daniel Osvaldo and Totti in attack, as the captain will become the second all-time top scorer in Serie A history if he scores this evening.
He is currently on 224 Serie A goals, one shy of Gunnar Nordahl’s tally.
Genoa are still unbeaten under Coach Ballardini, earning two victories and three draws.
Andreas Granqvist and Francelino Matuzalem are suspended for the Rossoblu, while Marco Rossi, Antonio Floro Flores, Ruben Olivera and Thomas Manfredini are injured.
Bosko Jankovic is back on the bench for the first time since suffering a muscular strain in December.
Roma: Stekelenburg; Piris, Burdisso, Romagnoli; Torosidis, De Rossi, Pjanic, Balzaretti; Lamela, Totti; Osvaldo
Roma bench: Goicoechea, Lobont, Dodò, Taddei, Bradley, Perrotta, Marquinho, Tachtsidis, Florenzi, Lucca, Lopez
Genoa: Frey; Bovo, Portanova, Moretti; Pisano, Kucka, Tozser, Vargas, Antonelli; Bertolacci; Borriello
Genoa bench: Tzorvas, Donnarumma, Ferronetti, Jankovic, Rigoni, Immobile, Jorquera, Cassani