Croatian Ivan Bebek will officiate Inter-Tottenham on Thursday, while Norwegian Tom Harald Hagen has the whistle for Lazio-Stuttgart.
UEFA have assigned the referees for this week’s Europa League second legs in the Round of 16.
Inter have to recover from a 3-0 pasting at White Hart Lane and step into San Siro at 18.00 GMT on Thursday.
The referee will be 36-year-old Croatian Ivan Bebek.
Lazio have a 2-0 first leg away victory to count on as they welcome Stuttgart to the Olimpico at 20.05 GMT.
The stadium will be empty, as UEFA rejected Lazio’s appeal against a two-match order to play behind closed doors due to the behaviour of their supporters.
Norwegian 35-year-old Tom Harald Hagen will officiate. He has been at the helm with Italian teams twice before, both victories for Milan against BATE Borisov in October 2011 and Udinese 3-0 at PAOK in February 2012.