Inter are again reduced to a bare bones squad against Tottenham in the Europa League and look to 18-year-old Mateo Kovacic.
The Nerazzurri’s hopes of qualification are hanging by a thread after a 3-0 first leg defeat at White Hart Lane. Kick-off is at 18.00 GMT.
They are at least boosted by the fact Gareth Bale is suspended, so there will be no repeat of his famous hat-trick at San Siro in the Champions League.
William Gallas and Emmanuel Adebayor step into the starting XI.
Andrea Stramaccioni has a lengthy injury list to deal with, including Diego Milito, Walter Samuel, Yuto Nagatomo, Matias Silvestre, Gaby Mudingayi and Joel Obi.
January signings Tommaso Rocchi, Zdravko Kuzmanovic and Ezequiel Schelotto are also unavailable for this tournament.
Andrea Ranocchia is on the bench after undergoing surgery for a fractured nose on Monday.
The focus is on 18-year-old midfielder Kovacic, who has so far struggled to make an impact in his performances since arriving for €10m in January.
He supports Rodrigo Palacio and Antonio Cassano, the only available forwards, while four of the seven on the bench are youth team players.
Inter: Handanovic; Jonathan, Juan Jesus, Chivu, Zanetti; Gargano, Kovacic, Cambiasso; Guarin; Palacio, Cassano
Inter bench: Belec, Ranocchia, Alvarez, Benassi, Pasa, Belloni, Colombi
Tottenham: Friedel; Walker, Gallas, Vertonghen, Naughton; Dembele, Parker, Livermore, Sigurdsson; Defoe, Adebayor
Tottenham bench: Lloris, Assou-Ekotto, Caulker, Huddlestone, Lennon, Holtby, Carroll