Milan try to get over Barcelona and close on second place in Serie A, while Palermo welcome back Coach Giuseppe Sannino.
This clash kicks off at San Siro at 14.00 GMT, click here for a match preview.
The Rossoneri had a rough week with their Champions League exit, humiliated 4-0 at Camp Nou.
Domestically they remain unbeaten in 2013 and have Mario Balotelli available to lead the attack.
Giampaolo Pazzini and Nigel De Jong are injured, while Kevin Constant sits out a ban following his red card against Genoa.
Mattia De Sciglio steps in and Kevin-Prince Boateng completes the trident with Stephan El Shaarawy.
Palermo are almost resigned to relegation and without a victory since November, but the home defeat to Siena prompted yet another change of management.
Sannino started the season and was fired after three games, then Gian Piero Gasperini was hired, sacked and re-hired following a 19-day spell with Alberto Malesani in charge.
On Monday Gasperini parted company with the club by mutual consent and Sannino was sensationally recalled to the bench.
He has an injury crisis on his hands, missing Fabrizio Miccoli, Andrea Dossena, Edgar Barreto, Abel Hernandez and Andrea Mantovani for this match.
Paulo Dybala starts with support from Josip Ilicic.
Milan: 32 Abbiati; 20 Abate, 25 Bonera, 17 Zapata, 2 De Sciglio; 16 Flamini, 18 Montolivo, 4 Muntari; 10 Boateng, 45 Balotelli, 92 El Shaarawy
Milan bench: 1 Amelia, 5 Mexes, 7 Robinho, 8 Nocerino, 12 Traoré, 19 Niang, 22 Bojan, 23 Ambrosini, 51 Petkovic, 76 Yepes, 77 Antonini, 81 Zaccardo
Palermo: 54 Sorrentino; 6 Munoz, 25 Von Bergen, 3 Aronica; 89 Morganella, 20 Arevalo Rios, 23 Donati, 28 Kurtic, 29 Garcia; 27 Ilicic, 9 Dybala
Palermo bench: 99 Benussi, 7 Viola, 14 Anselmo, 16 Fabbrini, 17 Boselli, 18 Faurlin, 19 Sperduti, 22 Nelson, 24 Malele, 30 Brichetto, 33 Formica, 50 Sanseverino