Roma aim to continue climbing up the table with Francesco Totti marking his 20th Serie A anniversary and could put the final nail in Palermo’s coffin.
It kicks off at the Stadio Barbera at 14.00 GMT, click here for a match preview.
The Giallorossi have transformed their campaign since Aurelio Andreazzoli took over from Zdenek Zeman and have won four of their last five games.
Marquinhos and Nico Lopez miss out, but Simone Perrotta is back and Miralem Pjanic and Mattia Destro are fit for the bench.
Totti aims to celebrate 20 years of Serie A football and does so with Erik Lamela and Alessandro Florenzi, as Pablo Daniel Osvaldo is yet again dropped.
Fabrizio Miccoli and Edgar Barreto are back for Palermo, as only long-term absentees Abel Hernandez and Andrea Mantovani are sidelined.
The Sicilians are propping up the table and without a victory since November, so relegation seems certain unless they can cause a huge upset this afternoon.
Palermo: 54 Sorrentino; 6 Munoz, 25 Von Bergen, 3 Aronica; 89 Morganella, 5 Barreto, 23 Donati, 28 Kurtic, 8 Dossena; 27 Ilicic, 10 Miccoli
Palermo bench: 99 Benussi, 7 Viola, 9 Dybala, 16 Fabbrini, 17 Boselli, 18 Faurlin, 22 Nelson, 24 Malele, 29 Garcia, 30 Brichetto, 33 Formica, 50 Sanseverino
Roma: 24 Stekelenburg; 23 Piris, 29 Burdisso, 5 Castan; 20 Perrotta, 16 De Rossi, 77 Tachtsidis, 7 Marquinho; 8 Lamela, 48 Florenzi; 10 Totti
Roma bench: 1 Lobont, 4 Bradley, 9 Osvaldo, 11 Taddei, 13 Goicoechea, 15 Pjanic, 22 Destro, 27 Dodò, 35 Torosidis, 42 Balzaretti, 46 Romagnoli, 47 Lucca
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £5,000 monthly.